منابع مشابه
Single-base mismatch detection based on charge transduction through DNA.
High-throughput DNA sensors capable of detecting single-base mismatches are required for the routine screening of genetic mutations and disease. A new strategy for the electrochemical detection of single-base mismatches in DNA has been developed based upon charge transport through DNA films. Double-helical DNA films on gold surfaces have been prepared and used to detect DNA mismatches electroch...
متن کاملDNA Mismatch Detection by Metal Ion Enhanced Impedance Analysis
Peng-Chung Jangjian, Tzeng-Feng Liu, Chuan-Mei Tsai, Mei-Yi Li, 2 Ming-Shih Tsai, Shin-Hua Tseng, Tsai-Mu Cheng, and Chia-Ching Chang 5, ∗ Department of Material Science and Engineering, National Chiao Tung University, Hsinchu, 30050, Taiwan National Nano Device Laboratories, Hsinchu, 30072, Taiwan Cabot Microelectronic, Chupei, Hsinchu Hsien, 302, Taiwan Department of Biological Science and Te...
متن کاملDNA mismatch repair.
DNA mismatch repair (MMR) is an evolutionarily conserved process that corrects mismatches generated during DNA replication and escape proofreading. MMR proteins also participate in many other DNA transactions, such that inactivation of MMR can have wide-ranging biological consequences, which can be either beneficial or detrimental. We begin this review by briefly considering the multiple functi...
متن کاملSnapShot: DNA Mismatch Repair
Mismatch Repair in Bacteria and Eukaryotes Mismatch repair in the bacterium Escherichia coli is initiated when a homodimer of MutS binds as an asymmetric clamp to DNA containing a variety of base-base and insertion-deletion mismatches. The MutL homodimer then couples MutS recognition to the signal that distinguishes between the template and nascent DNA strands. In E. coli, the lack of adenine m...
متن کاملDNA mismatch correction.
PERSPECTIVES ANDUMMARY .............................................................. 435 BIOLOGY OFMISMATCH ORRECTION ................................................... 437 Evidence for Mismatch Processing in Vivo .................................................. 437 Postreplication Repair of Biosynthetic Errors ............................................... 438 dam-Independent Mismatch Cor...
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ژورنال
عنوان ژورنال: Nature Biotechnology
سال: 2000
ISSN: 1087-0156,1546-1696
DOI: 10.1038/80186